Beethoven's Grosse Fuge is, by a wide margin, the most inscrutable major work by a major composer of which I am aware. In fact, next to inscrutable in the dictionary there could very well be the score. I had certainly heard
about Die Grosse Fuge, but I had never heard it, and in fact to the best of my knowledge I had never heard any Beethoven String Quartets when, in my 20s, I bought my first set at the used record store. The first track I put on was Grosse Fuge and I listened for a couple of minutes in growing disbelief to sounds so hideous I couldn't imagine they were written by my hero, Ludwig van, and recorded by professional musicians. It turns out I was in pretty good company because pretty much everyone ever has had a similar reaction.
It took me decades before I finally warmed up to Beethoven's Late Quartets, and even longer before I made friends with the Great Fugue. It was the recording by the Cleveland Quartet that finally did it for me.

16/44 FLAC rip from CD
Today I can say I listen to it, occasionally, and appreciate it. But it would be a stretch to say I like it.