I cannot say from experience, but it is hard for me to imagine two speakers being more different in design. In that, I mean that the NFX is closer to an open baffle speaker and should have a large dispersion pattern. The DNA is quite opposite in that it would have good dispersion, but much more directed, at least in the mid range and treble. I would also expect that the DNA would have visceral bass compared to the NFX.
As it turns out, I will be building the DNA speaker in the near future. I would also mention that I presently own the ZOB which is an open baffle design. The comparison of these two speakers will be of great interest to me in the future.