i haven't used that particular driver, but if it's not free-air, it will work. i'm not sure if you'll hit the same spl with iso loading. actually if the iso group gets the same power you'll hit 3db lower compared to a single driver getting the same power.
i think that if spl is you goal you should try either 2 DB12s or one wicked one with taller panels and angled baffles.

not really, mainly for increaseing volume of the sealed portion.

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now that's "stupid"  :D
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then i say clamshell'em orions and put'em in a db12