I pretty much set it and forget it!

I do know what you mean, it can be quite intimidating and awkward to use all these things.
The ZBox is easy for me, I pretty much have the gain turned all the way up and don't mess with that, and mine has a second input added and I can toggle between two sources that way. Currently I have the CSP2 output going to that and the analog out from my Sony BDP-S5000ES Blu-Ray player. I most often have it switched the CSP2 and don't have to mess with that.
The ZDAC-1I use to switch between the coaxial digital out from the Blu-Ray player and the glass optical out from my DVR. I switch back and forth from those with the on switch on the front.
I have the analog out from my Sony SCD-XA5400ES SACD player going into one input of the CSP2 and the analog out of the ZDAC-1 going into the other. I switch between those to hear each source. I have the gain pots for the CSP2 set and generally don't experiment with them much. At the moment they're about 3/4 of the way turned up.
On the Torii Mk III I generally have the speaker ohmage switches and the front bias switch in one position and I don't mess with them. Right now I have the lower ohm position and the neutral bias position chosen. This seems to be the most accurate tonally for the material I use with the tube complement I have.
I'm not using the second input on the Torii at the moment.
So once set up I just use the volume knob and toggle switch sources on the CSP2, ZDAC-1 and ZBox. I have these behind the Samson rack and the TV and it's not easy to reach but I've gotten really used to it and it's very easy for me now.
It's an interesting question you pose, and I think you alone have the answer for your room and components and their placement!